Botulinum Toxin – a promising new treatment for overactive bladder

Bladder instillation of liposome encapsulated onabotulinumtoxina improves overactive bladder symptoms: a prospective, multicenter, double-blind, randomized trial.

PURPOSE Cystoscopic intradetrusor injection of botulinum toxin has helped patients with refractory overactive bladder but with the increased risks of urinary tract infection and urinary retention. We assessed whether catheter instillation of 200 U onabotulinumtoxinA formulated with liposomes is safe and effective for the treatment of overactive bladder. MATERIALS AND METHODS This 2-center, do...

Botulinum toxin A for the Treatment of Overactive Bladder

The standard treatment for overactive bladder starts with patient education and behavior therapies, followed by antimuscarinic agents. For patients with urgency urinary incontinence refractory to antimuscarinic therapy, currently both American Urological Association (AUA) and European Association of Urology (EAU) guidelines suggested that intravesical injection of botulinum toxin A should be of...

Intravesical Electromotive Botulinum Toxin in Women with Overactive Bladder – A Pilot Study

Management of overactive bladder (OAB) can be difficult, and when primary treatment has failed to give sufficient improvement, cystoscopic injection of botulinum toxin into the bladder wall is now a well established treatment option [1-4] . This is a minimally invasive outpatient or day case procedure. Among the currently available botulinum toxin preparations only onabotulinum toxin A (Botox®)...

Botulinum Toxin for an Overactive Bladder

RE: Efficacy of botulinum toxin type A 100 units versus 200 units for treatment of refractory idiopathic overactive bladder

We read with great interest in the article “Efficacy of botulinum toxin type A 100 Units versus 200 units for treatment of refractory idiopathic overactive bladder”. Osama Abdelwahab, et al. (1) nicely presented the treatment outcomes in this well conducted randomized controlled study. Lack of voiding diary is one of the weak points of the article. Number of incontinence episode or functional b...